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Genotyping and Microbiome

Genotyping and Microbiome

Genotyping and Microbiome

There is growing evidence to suggest the association of host genotype with the microbial community structure. A well-characterized association of this type in western population is FUT2 gene polymorphism. This gene encodes for an enzyme fucosyltransferase-2 (α-1,2-fucosyl transferase) which is involved in synthesis of the ABO antigen. Single Nucleotide Polymorphism (SNP) in the exonic region of this gene is also known to be associated with certain gastrointestinal diseases such as Inflammatory Bowel Disease (IBD) and Crohn’s disease. It is evident from few studies that this molecule is also secreted from mucosal surfaces such as the intestinal lining and may serve as the source of glycans and adhesion site to gut microbes like lactic acid bacteria. Thus to explore this host microbe interaction, as a part of a cross sectional study, our focus has also been on understanding the influence of FUT2 (Fucosyl transferase) secretor status on the gut microbial flora (Kumbhare et al. 2017).